Enroth H, Eriksson I, Held M, Nyrén O, Engstrand L, Hansson L E, Gyllensten U B
Department of Genetics and Pathology, Section of Medical Genetics, Rudbeck Laboratory, Uppsala, Sweden.
Cancer Res. 2001 Mar 15;61(6):2684-9.
DNA and sera from 130 cases of gastric cancer and 263 population-based controls were analyzed to study the association of HLA class II DR-DQ alleles with Helicobacter pylori (Hp) infection and the risk for gastric cancer. Presence of the DQA1*0102 allele was inversely and significantly associated with Hp seropositivity (P = 2 x 10(-5)), which is an independent replication of previous findings. However, this inverse relationship with Hp did not correspond with a reduced risk of gastric cancer. At the DRB1 locus, the *1601 allele was significantly associated with an increased gastric cancer risk with an odds ratio (95% confidence interval) of 8.7 (range, 2.7-28.0). The effect of *1601 was more pronounced among Hp-negative subjects, and the association was stronger with the diffuse, rather than with the intestinal, histological type of gastric cancer. Because none of the HLA alleles were associated with both Hp infection and gastric cancer, the HLA DR-DQ alleles are linked with gastric cancer risk through other mechanisms than an increased susceptibility to Hp infection.
对130例胃癌患者及263例基于人群的对照者的DNA和血清进行分析，以研究人类白细胞抗原（HLA）II类DR-DQ等位基因与幽门螺杆菌（Hp）感染及胃癌风险之间的关联。DQA1*0102等位基因的存在与Hp血清阳性呈显著负相关（P = 2×10⁻⁵），这是对先前研究结果的独立重复验证。然而，这种与Hp的负相关关系与降低的胃癌风险并不相符。在DRB1基因座，*1601等位基因与胃癌风险增加显著相关，优势比（95%置信区间）为8.7（范围为2.7 - 28.0）。*1601的作用在Hp阴性受试者中更为明显，且与弥漫型而非肠型胃癌组织学类型的关联更强。由于没有一个HLA等位基因与Hp感染和胃癌均相关，因此HLA DR-DQ等位基因与胃癌风险的关联是通过不同于增加对Hp感染易感性的其他机制实现的。
