Maskarinec G, Lyu L C, Meng L, Theriault A, Ursin G
Cancer Research Center, University of Hawaii, Honolulu 96813, USA.
Ethn Dis. 2001 Winter;11(1):44-50.
This cross-sectional study explored the relation between mammographic densities (a predictor of breast cancer risk), ethnicity, and dietary factors among women in Hawaii. Thirty-nine postmenopausal women with Japanese, Chinese, Caucasian, and Native Hawaiian ancestry who had received a screening mammogram completed a medical, reproductive, and dietary history. Using a computerized method, we determined the total and the dense area of the breast and calculated the ratio between the two. Blood lipids were measured using standard methods. For statistical analysis, we applied analysis of variance and multiple linear regression. Whereas the mean dense area of the breast was one third smaller in Asian than in Caucasian and Native Hawaiian women, the percent of the breast occupied by dense tissue in the Asian women was slightly higher than in the Caucasian/Hawaiian group, possibly a result of the Asian women's smaller breast size. The exploratory analysis indicated inverse relations of body mass index, high-density lipoprotein cholesterol (HDLC), age at menarche, and soy intake with mammographic densities, as well as direct relations of estrogen use and family history with mammographic densities. The results of this study suggest that variations in these factors may be responsible for ethnic differences in mammographic densities and in breast cancer risk.
这项横断面研究探讨了夏威夷女性的乳房X线密度（乳腺癌风险的一个预测指标）、种族和饮食因素之间的关系。39名有日本、中国、白种和夏威夷原住民血统的绝经后女性接受了乳房X线筛查，并完成了医疗、生殖和饮食史调查。我们采用计算机化方法测定乳房的总面积和致密区面积，并计算两者的比例。采用标准方法测量血脂。在统计分析中，我们应用了方差分析和多元线性回归。亚洲女性乳房的平均致密区面积比白种和夏威夷原住民女性小三分之一，然而，亚洲女性乳房致密组织所占百分比略高于白种/夏威夷人群组，这可能是因为亚洲女性乳房尺寸较小。探索性分析表明，体重指数、高密度脂蛋白胆固醇（HDLC）、初潮年龄和大豆摄入量与乳房X线密度呈负相关，而雌激素使用和家族史与乳房X线密度呈正相关。本研究结果表明，这些因素的差异可能是导致乳房X线密度和乳腺癌风险存在种族差异的原因。
