Maskarinec G, Meng L
Cancer Research Center of Hawaii, Honolulu 96813, USA.
Breast Cancer Res Treat. 2000 Sep;63(2):153-61. doi: 10.1023/a:1006486319848.
Epidemiologic evidence suggests that mammographic densities are markers of breast cancer risk. This project investigated the relation between breast cancer and densities in women of Chinese, Japanese, Filipino, Native Hawaiian, and Caucasian ancestry. Mammograms from breast cancer cases and from healthy controls were compared using a computer-assisted method of mammographic density assessment. From 1991 to 1997, 935 cases of breast cancer were diagnosed at Kaiser Permanente in Hawaii; for 647 (69%) subjects, a control woman matched by ethnicity, year of mammogram, and age was identified. Conditional multiple logistic regression was applied to estimate the relative risk of developing breast cancer. Breast cancer risk was associated with percent densities and with the size of the dense areas. Women in the category with the most densities experienced a twofold risk of developing breast cancer as compared to women with the least densities. Adjustment for risk factors reduced the strength of the association. Odds ratios were of similar magnitude in Asian women as in Caucasian/Native Hawaiian women, but they were not statistically significant. The results of this study indicate that the associations of breast cancer risk with the magnitude of the dense areas and with the percent densities are of similar strength in women of different ethnicities although density levels vary by ethnicity.
流行病学证据表明，乳腺钼靶密度是乳腺癌风险的标志物。本项目调查了华裔、日裔、菲律宾裔、夏威夷原住民和高加索裔女性中乳腺癌与乳腺密度之间的关系。使用计算机辅助乳腺密度评估方法，对乳腺癌病例和健康对照者的乳房X光片进行了比较。1991年至1997年期间，夏威夷凯撒医疗中心诊断出935例乳腺癌病例；其中647例（69%）受试者找到了按种族、乳房X光检查年份和年龄匹配的对照女性。应用条件多元逻辑回归来估计患乳腺癌的相对风险。乳腺癌风险与密度百分比以及致密区域的大小有关。与密度最低的女性相比，密度最高的女性患乳腺癌的风险高出两倍。对风险因素进行调整后，关联强度有所降低。亚洲女性的优势比与高加索/夏威夷原住民女性的相似，但无统计学意义。本研究结果表明，尽管不同种族的密度水平有所不同，但在不同种族的女性中，乳腺癌风险与致密区域大小和密度百分比之间的关联强度相似。
