Konishi E, Kusuzaki K, Murata H, Tsuchihashi Y, Beabout J W, Unni K K
Department of Pathology, Kyoto Prefectural University of Medicine, Japan.
Skeletal Radiol. 2001 Jan;30(1):39-43. doi: 10.1007/s002560000298.
A 53-year-old woman had extraskeletal osteosarcoma that developed from a soft tissue bony mass present on the volar aspect of the left wrist for 4 years. Initially, the bony mass was soft and movable, but during the first year it became hard and fixed. The patient had no history of trauma. Because the lesion did not grow or cause any symptoms, the patient did not come to the hospital until 4 years after she first noticed the lesion. Radiologically, the bony mass had features characteristic of mature myositis ossificans, showing "eggshell" ossification. A nonmineralized soft tissue mass occurred between the surface of the radius and the bony shell. Histologically, a high-grade osteosarcoma was present between the surface of the radius and the well-differentiated bone tissue, which included fatty and hematopoietic marrow. All the findings indicated that our patient had an extremely rare case of malignant transformation of myositis ossificans.
一名53岁女性患有骨外骨肉瘤，其起源于左手腕掌侧存在4年的软组织骨块。最初，该骨块质地柔软且可活动，但在第一年变得坚硬且固定。患者无外伤史。由于病变未生长或引起任何症状，患者在首次发现病变4年后才前来医院。放射学检查显示，该骨块具有成熟骨化性肌炎的特征性表现，呈现“蛋壳样”骨化。在桡骨表面与骨壳之间出现了一个无矿化的软组织肿块。组织学检查发现，在桡骨表面与分化良好的骨组织（包括脂肪和造血骨髓）之间存在高级别骨肉瘤。所有这些发现表明，我们的患者患有极为罕见的骨化性肌炎恶变病例。
