Salomão Diva R, Schmitt Nicholas J, Wenger Doris E, Schlafmann Sue, Fritchie Karen
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Ocul Oncol Pathol. 2019 Feb;5(2):114-118. doi: 10.1159/000487544. Epub 2018 Jul 26.
A 60-year-old male presented with an increasingly painful and swollen phthisical eye. Enucleation revealed a large mass obliterating the eye with extension into the adjacent extraocular muscle. Histologic examination showed high-grade osteosarcoma. Systemic work-up showed no disease elsewhere, and a diagnosis of orbital extraskeletal osteosarcoma was rendered. Complete resection was not possible, and neoadjuvant radiation was given. The patient subsequently developed pulmonary metastasis and died of disease 5 months after initial diagnosis. Given the highly aggressive nature of this malignancy, raising awareness that extraskeletal osteosarcoma may arise in the background of phthisis bulbi will facilitate timely and accurate diagnosis and treatment.
一名60岁男性因患眼疼痛和肿胀日益加重前来就诊。眼球摘除术后发现一个巨大肿物，占据眼球并延伸至相邻眼外肌。组织学检查显示为高级别骨肉瘤。全身检查未发现其他部位有病变，诊断为眼眶骨外骨肉瘤。无法进行完整切除，遂给予新辅助放疗。患者随后出现肺转移，在初次诊断后5个月死于该病。鉴于这种恶性肿瘤具有高度侵袭性，提高对眼球痨背景下可能发生骨外骨肉瘤的认识将有助于及时、准确的诊断和治疗。
