Menendez-Vallina R, Perillan C, Arguelles J, Esteban I, Brime J I, Vijande M, Vega J A
Departmento de Biologia Funcional (Area de Fisiologia) Facultad de Oviedo, c/Julian Claveria, s/n E-33006, Oviedo, Spain.
Neurosci Lett. 2001 Apr 20;302(2-3):125-8. doi: 10.1016/s0304-3940(01)01674-3.
Partial aortic ligature causes an increase in water and sodium intake. Circumventricular brain regions are known to be involved in the regulation of these processes. In this work we use c-fos-like immunoreactivity to detect active areas involved in the long-term control of increased water and sodium intake due to partial aortic ligature. A significant increase in water intake was found on the first day after the induction, while natriophilia was observed on the fourth day. c-fos-like immunoreactivity was found selectively in the subfornical organ, the organum vasculosum of the lamina terminalis, the medial preoptic area, and the choroid plexus of the third ventricle. Present results provide further evidence for the involvement of circumventricular organs and the preoptic area in the regulation of hydromineral balance. Moreover, they suggest a maintained and long-term regulation of sodium intake by these same brain areas.
部分主动脉结扎会导致水和钠摄入量增加。已知脑室周围脑区参与这些过程的调节。在这项研究中，我们使用c-fos样免疫反应性来检测因部分主动脉结扎导致水和钠摄入量增加的长期控制中涉及的活跃区域。诱导后第一天发现水摄入量显著增加，而在第四天观察到嗜钠现象。在穹窿下器官、终板血管器、视前内侧区和第三脑室脉络丛中选择性地发现了c-fos样免疫反应性。目前的结果为脑室周围器官和视前区参与水盐平衡调节提供了进一步的证据。此外，它们表明这些相同的脑区对钠摄入量进行持续的长期调节。
