Dardari R, Khyatti M, Jouhadi H, Benider A, Ettayebi H, Kahlain A, Mansouri A, El Gueddari B, Benslimane A
Institut Pasteur du Maroc, 1 Rue Abou Kacem Ez-Zahraoui, B.P. 120-Casablanca, Morocco.
Int J Cancer. 2001 Apr 15;92(2):294-7. doi: 10.1002/1097-0215(200102)9999:9999<::aid-ijc1177>3.0.co;2-9.
Previous reports demonstrated an association between the human leukocyte antigen (HLA) and risk for nasopharyngeal carcinoma (NPC) among the Chinese in Singapore, a population with a high incidence of this malignancy. In our study, we assess the association between HLA and NPC in Morocco, a median-prevalence area for this cancer, where NPC presents the particularity of also affecting young individuals. Using the standard microlympho-cytotoxicity test, we typed a total of 154 Moroccan NPC patients and 257 unrelated healthy controls for their HLA-A and B antigens. The results of these analyses show that the frequencies of HLA-A10, HLA-B13 and HLA-B18 were found to be higher in the NPC group than in the control group, whereas HLA-A9 was associated with a decreased risk. After correction for the number of specificities tested, these differences were statistically significant only for HLA-B18 (corrected p value [pc] < 0.023, relative risk [RR] = 4.14) and HLA-A9 (pc < 0.023, RR = 0.45). The comparison of the distribution of the HLA antigens in younger and older cohorts of patients shows that the incidence of HLA-A10 and HLA- B18 was higher in the older group, whereas the frequencies of HLA-A19 and HLA-B13 were significantly higher in younger patients compared with controls. The presence of both HLA-A19 and HLA-B13 phenotypes correlated with an increased risk of developing NPC among overall patients compared with controls. According to the sex distribution, increased frequency of HLA-B18 was found in male and female NPC patients compared with controls, whereas the frequency of HLA-A10 was higher only in male NPC patients compared with controls.
先前的报告表明，在新加坡的华人中，人类白细胞抗原（HLA）与鼻咽癌（NPC）风险之间存在关联，该人群中这种恶性肿瘤的发病率很高。在我们的研究中，我们评估了在摩洛哥HLA与NPC之间的关联，摩洛哥是这种癌症的中等流行地区，在那里NPC还具有影响年轻人的特殊性。我们使用标准的微量淋巴细胞毒性试验，对总共154名摩洛哥NPC患者和257名无关的健康对照进行了HLA-A和B抗原分型。这些分析结果显示，NPC组中HLA-A10、HLA-B13和HLA-B18的频率高于对照组，而HLA-A9与风险降低相关。在对所检测的特异性数量进行校正后，这些差异仅对HLA-B18（校正p值[pc]<0.023，相对风险[RR]=4.14）和HLA-A9（pc<0.023，RR=0.45）具有统计学意义。对年轻和老年患者队列中HLA抗原分布的比较表明，老年组中HLA-A10和HLA-B18的发生率较高，而与对照组相比，年轻患者中HLA-A19和HLA-B13的频率显著更高。与对照组相比，HLA-A19和HLA-B13两种表型的存在与总体患者中发生NPC的风险增加相关。根据性别分布，与对照组相比，男性和女性NPC患者中HLA-B18的频率均增加，而与对照组相比，HLA-A10的频率仅在男性NPC患者中较高。
