突尼斯人群中HLA - A/-B抗原、-DRB1等位基因与鼻咽癌的关联
Association between HLA-A/-B antigens and -DRB1 alleles and nasopharyngeal carcinoma in Tunisia.
作者信息
Mokni-Baizig N, Ayed K, Ayed F B, Ayed S, Sassi F, Ladgham A, Bel Hadj O, El May A
机构信息
Institut de Carcinologie Salah Azaiz, Tunis, Tunisie.
出版信息
Oncology. 2001;61(1):55-8. doi: 10.1159/000055353.
Using serologic and molecular methods, 45 nasopharyngeal carcinoma (NPC) patients were typed for HLA class I and class II and were compared to 100 unrelated normal Tunisians. Our results showed that the antigen frequency of HLA-B13 and allelic frequencies of DRB103, DRB115 were significantly higher in the NPC patients than in the control group (15.5 vs. 4; 26.4 vs. 11.5, and 14.4 vs. 6.5%, respectively) probably indicating a positive association with NPC. Moreover, we observed that HLA-A23 was absent in our NPC sample and was present in 18% of normal controls, and HLA-DRB1*11 was less frequent among the patients compared to the controls (5.5 vs. 14%) suggesting a protective effect of this association with NPC.
采用血清学和分子方法，对45例鼻咽癌（NPC）患者进行了HLAⅠ类和Ⅱ类分型，并与100名无关的突尼斯正常人进行比较。我们的结果显示，NPC患者中HLA - B13的抗原频率以及DRB103、DRB115的等位基因频率显著高于对照组（分别为15.5%对4%；26.4%对11.5%，以及14.4%对6.5%），这可能表明其与NPC呈正相关。此外，我们观察到在我们的NPC样本中不存在HLA - A23，而在18%的正常对照中存在，并且与对照组相比，患者中HLA - DRB1*11的频率较低（5.5%对14%），这表明这种关联对NPC具有保护作用。
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