Sundström J, Salminen E, Nurmi M, Toppari J, Pöllänen P, Pelliniemi L J, Huhtala S, Rajala P, Laato M
Department of Anatomy, University of Turku, Finland.
Scand J Urol Nephrol. 2001 Feb;35(1):21-5. doi: 10.1080/00365590151030723.
This study investigated the outcome of testicular cancer treatment in Finland.
Data on 88 testicular cancer patients treated in Turku University Central Hospital between 1976 and 1992 were studied to analyse outcome and survival.
The histological diagnosis was seminoma for 39 patients and non-seminoma for 49 patients. Two seminoma patients relapsed (5%) and one patient died of progressive disease (3%; initially stage II seminoma). Eleven non-seminoma patients relapsed (22%), nine of whom were cured with chemotherapy. Four non-seminoma patients died of progressive disease (8%; initially one stage I non-seminoma and three stage III non-seminomas). The median time to relapse after the completion of treatment was 9 months (range 3-50 months). Non-seminoma patients had significantly more relapses than seminoma patients (p = 0.03). Most relapses (73% of the non-seminoma relapses) were found among the stage I non-seminoma patients who had not received adjuvant chemotherapy, while none of the stage I seminoma patients relapsed (p = 0.007).
Close surveillance is important for all non-seminoma patients to guarantee the early detection and treatment of recurrent disease. Treatment and surveillance should be covered by national guidelines and be conducted in centres with special interest in this rare but mostly curable cancer.
本研究调查了芬兰睾丸癌的治疗结果。
研究了1976年至1992年间在图尔库大学中心医院接受治疗的88例睾丸癌患者的数据，以分析治疗结果和生存率。
组织学诊断为精原细胞瘤的患者有39例，非精原细胞瘤的患者有49例。两名精原细胞瘤患者复发（5%），一名患者死于疾病进展（3%；最初为II期精原细胞瘤）。11名非精原细胞瘤患者复发（22%），其中9例通过化疗治愈。4名非精原细胞瘤患者死于疾病进展（8%；最初1例为I期非精原细胞瘤，3例为III期非精原细胞瘤）。治疗结束后复发的中位时间为9个月（范围3 - 50个月）。非精原细胞瘤患者的复发明显多于精原细胞瘤患者（p = 0.03）。大多数复发（73%的非精原细胞瘤复发）发生在未接受辅助化疗的I期非精原细胞瘤患者中，而I期精原细胞瘤患者无一复发（p = 0.007）。
对所有非精原细胞瘤患者进行密切监测对于确保复发性疾病的早期发现和治疗很重要。治疗和监测应遵循国家指南，并在对这种罕见但大多可治愈的癌症有特别关注的中心进行。
