Dieckmann Klaus-Peter, Richter-Simonsen Hanna, Kulejewski Magdalena, Ikogho Raphael, Zecha Henrik, Anheuser Petra, Pichlmeier Uwe, Isbarn Hendrik
Albertinen Krankenhaus Hamburg, Klinik für Urologie, Hamburg, Germany.
Asklepios Klinik Altona, Hodentumorzentrum Hamburg, Hamburg, Germany.
Urol Int. 2018;100(4):409-419. doi: 10.1159/000488284. Epub 2018 Apr 12.
Clinical characteristics of testicular germ cell tumours (GCTs) apparently change over time, and some vary geographically. The aim of this study is to document the clinical profile of contemporary GCT patients.
Four hundred twenty-two Caucasian GCT-patients treated in one German centre during 2000-2017, were analysed in terms of patient-age, laterality, histology, tumour-size, clinical stages (CS), pathological (pT)-stages and serum biomarker expression. The results were analysed descriptively and compared with the literature.
Median age was 36 years and 60.2% had seminoma. Βeta-human chorionic gonadotropin was expressed in 37.9% and alpha Fetoprotein in 25.6%. CS1 presenting stage was 66.6% of all GCT patients, 79.1% in seminoma, and 47.6% in nonseminoma. Tumour size was significantly associated with pT-stages and CS. Patients >50 years had significantly more seminoma (77.6%) than younger ones (57.9%). Comparison with literature data revealed a shifting towards higher age, lower CS, higher proportion of seminoma and striking differences of characteristics among geographic regions.
A typical contemporary clinical profile of testicular GCTs is presented in this study. Median age, relative incidence of seminoma and proportion of CS1 appear to be increasing over time. Striking differences among ethnic groups regarding the characteristics of GCT require further investigation.
睾丸生殖细胞肿瘤（GCTs）的临床特征似乎随时间变化，且在不同地区存在差异。本研究旨在记录当代GCT患者的临床特征。
对2000年至2017年期间在德国一个中心接受治疗的422例白种人GCT患者，从患者年龄、患侧、组织学、肿瘤大小、临床分期（CS）、病理（pT）分期和血清生物标志物表达等方面进行分析。对结果进行描述性分析并与文献进行比较。
中位年龄为36岁，60.2%为精原细胞瘤。37.9%的患者β-人绒毛膜促性腺激素呈阳性表达，25.6%的患者甲胎蛋白呈阳性表达。CS1期占所有GCT患者的66.6%，精原细胞瘤患者中占79.1%，非精原细胞瘤患者中占47.6%。肿瘤大小与pT分期和CS显著相关。年龄大于50岁的患者精原细胞瘤比例（77.6%）显著高于年轻患者（57.9%）。与文献数据比较显示，发病年龄呈上升趋势，CS降低，精原细胞瘤比例升高，且不同地理区域特征存在显著差异。
本研究呈现了当代睾丸GCT的典型临床特征。中位年龄、精原细胞瘤相对发病率和CS1期比例似乎随时间增加。不同种族间GCT特征的显著差异需要进一步研究。
