异烟肼对结核分枝杆菌H37Ra中单不饱和长链脂肪酸合成的抑制作用。
Isoniazid inhibition of the synthesis of monounsaturated long-chain fatty acids in Mycobacterium tuberculosis H37Ra.
作者信息
Davidson L A, Takayama K
出版信息
Antimicrob Agents Chemother. 1979 Jul;16(1):104-5. doi: 10.1128/AAC.16.1.104.
Abstract
Isoniazid inhibited C(24) and C(26) monounsaturated fatty acid synthesis in Mycobacterium tuberculosis H37Ra. Time courses of this inhibition and that of mycolic acid synthesis were similar.
摘要
异烟肼抑制结核分枝杆菌H37Ra中C(24)和C(26)单不饱和脂肪酸的合成。这种抑制作用的时间进程与分枝菌酸合成的时间进程相似。
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本文引用的文献
1
The thin-layer chromatographic separation of fatty acid methyl esters according to both chain length and unsaturation.
J Chromatogr. 1966 Jan;21(1):141-3. doi: 10.1016/s0021-9673(01)91277-4.
2
Inhibition by isoniazid of synthesis of mycolic acids in Mycobacterium tuberculosis.异烟肼对结核分枝杆菌中分枝菌酸合成的抑制作用。
J Gen Microbiol. 1970 Sep;63(1):41-8. doi: 10.1099/00221287-63-1-41.
3
Chemical analyses of mycobacterial cell walls.分枝杆菌细胞壁的化学分析
Biochim Biophys Acta. 1968 Apr 16;158(1):130-43. doi: 10.1016/0304-4165(68)90080-9.
4
Selective action of isoniazid on the synthesis of cell wall mycolates in mycobacteria.异烟肼对分枝杆菌细胞壁霉菌酸合成的选择性作用。
Ann N Y Acad Sci. 1974 May 10;235(0):426-38. doi: 10.1111/j.1749-6632.1974.tb43281.x.
5
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Antimicrob Agents Chemother. 1972 Jul;2(1):29-35. doi: 10.1128/AAC.2.1.29.
6
Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties.分枝杆菌及相关生物体的细胞壁；化学性质与免疫刺激特性
Mol Cell Biochem. 1975 May 30;7(2):87-104. doi: 10.1007/BF01792076.
7
Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis.异烟肼在结核分枝杆菌中分枝菌酸合成过程中的抑制作用位点。
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8
Isolation and characterization of the monounsaturated long chain fatty acids of Mycobacterium tuberculosis.
Lipids. 1978 Sep;13(9):575-9. doi: 10.1007/BF02535818.
9
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10
Characterization of the purified components of a new homologous series of alpha-mycolic acids from Mycobacterium tuberculosis H37Ra.
J Biol Chem. 1978 Aug 10;253(15):5411-7.
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