• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Isoniazid inhibition of the synthesis of monounsaturated long-chain fatty acids in Mycobacterium tuberculosis H37Ra.异烟肼对结核分枝杆菌H37Ra中单不饱和长链脂肪酸合成的抑制作用。
Antimicrob Agents Chemother. 1979 Jul;16(1):104-5. doi: 10.1128/AAC.16.1.104.
2
Effect of low temperature on growth, viability, and synthesis of mycolic acids of Mycobacterium tuberculosis strain H37Ra.低温对结核分枝杆菌H37Ra菌株生长、活力及分枝菌酸合成的影响
Am Rev Respir Dis. 1978 Jul;118(1):113-7. doi: 10.1164/arrd.1978.118.1.113.
3
Relationship between the uptake of isoniazid and its action on in vivo mycolic acid synthesis in Mycobacterium tuberculosis.异烟肼摄取与其对结核分枝杆菌体内分枝菌酸合成作用之间的关系。
Antimicrob Agents Chemother. 1972 Dec;2(6):438-41. doi: 10.1128/AAC.2.6.438.
4
Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis.异烟肼对结核分枝杆菌体内分枝菌酸合成、细胞生长及活力的影响。
Antimicrob Agents Chemother. 1972 Jul;2(1):29-35. doi: 10.1128/AAC.2.1.29.
5
Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis.异烟肼在结核分枝杆菌中分枝菌酸合成过程中的抑制作用位点。
J Lipid Res. 1975 Jul;16(4):308-17.
6
Selective action of isoniazid on the synthesis of cell wall mycolates in mycobacteria.异烟肼对分枝杆菌细胞壁霉菌酸合成的选择性作用。
Ann N Y Acad Sci. 1974 May 10;235(0):426-38. doi: 10.1111/j.1749-6632.1974.tb43281.x.
7
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis.卡索A（KasA）和卡索B（KasB）在结核分枝杆菌中分枝菌酸生物合成及异烟肼耐药性中的作用
Tuberculosis (Edinb). 2002;82(4-5):149-60. doi: 10.1054/tube.2002.0333.
8
Effects of isoniazid on mycolic acid synthesis in Mycobacterium tuberculosis and on its cell envelope.异烟肼对结核分枝杆菌中分枝菌酸合成及其细胞壁的影响。
Biochem J. 1970 Apr;117(2):27P. doi: 10.1042/bj1170027pa.
9
Restoration of mycolate synthetase activity in Mycobacterium tuberculosis exposed to isoniazid.在暴露于异烟肼的结核分枝杆菌中恢复分枝菌酸合成酶活性。
Am Rev Respir Dis. 1974 Jul;110(1):43-8. doi: 10.1164/arrd.1974.110.1.43.
10
In Vitro Effect of DFC-2 on Mycolic Acid Biosynthesis in .DFC - 2对……中分枝菌酸生物合成的体外效应
J Microbiol Biotechnol. 2017 Nov 28;27(11):1932-1941. doi: 10.4014/jmb.1705.05013.

引用本文的文献

1
Isoniazid-historical development, metabolism associated toxicity and a perspective on its pharmacological improvement.异烟肼——历史发展、代谢相关毒性及其药理学改进展望
Front Pharmacol. 2024 Sep 19;15:1441147. doi: 10.3389/fphar.2024.1441147. eCollection 2024.
2
Antibiotic resistance in alters tolerance to cell wall-targeting inhibitors.抗生素耐药性改变了对细胞壁靶向抑制剂的耐受性。
JAC Antimicrob Resist. 2024 Jun 4;6(3):dlae086. doi: 10.1093/jacamr/dlae086. eCollection 2024 Jun.
3
Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives.新型酰基酰肼和 1,3,4-恶二唑衍生物的合成、表征和生物活性。
Molecules. 2020 Jul 21;25(14):3308. doi: 10.3390/molecules25143308.
4
Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.结核分枝杆菌对异烟肼和乙硫异烟胺的耐药性：基因、突变和因果关系。
Microbiol Spectr. 2014 Aug;2(4):MGM2-0014-2013. doi: 10.1128/microbiolspec.MGM2-0014-2013.
5
Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.结核病药物研发：基于机制范式的历史与演进
Cold Spring Harb Perspect Med. 2015 Apr 15;5(8):a021147. doi: 10.1101/cshperspect.a021147.
6
Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis.结核分枝杆菌细胞包膜生物发生靶向治疗的研究进展。
Future Microbiol. 2013 Jul;8(7):855-75. doi: 10.2217/fmb.13.52.
7
Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.耻垢分枝杆菌mymA操纵子对豚鼠脾脏中结核分枝杆菌适当的细胞壁超微结构和持续性的需求。
J Bacteriol. 2005 Jun;187(12):4173-86. doi: 10.1128/JB.187.12.4173-4186.2005.
8
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.结核分枝杆菌中分枝菌酸的合成与加工途径。
Clin Microbiol Rev. 2005 Jan;18(1):81-101. doi: 10.1128/CMR.18.1.81-101.2005.
9
Isoniazid activation defects in recombinant Mycobacterium tuberculosis catalase-peroxidase (KatG) mutants evident in InhA inhibitor production.重组结核分枝杆菌过氧化氢酶-过氧化物酶（KatG）突变体中的异烟肼激活缺陷在InhA抑制剂产生中明显可见。
Antimicrob Agents Chemother. 2003 Feb;47(2):670-5. doi: 10.1128/AAC.47.2.670-675.2003.
10
Loci of Mycobacterium avium ser2 gene cluster and their functions.鸟分枝杆菌血清型2基因簇的位点及其功能。
J Bacteriol. 1994 Aug;176(16):4803-8. doi: 10.1128/jb.176.16.4803-4808.1994.

本文引用的文献

1
The thin-layer chromatographic separation of fatty acid methyl esters according to both chain length and unsaturation.
J Chromatogr. 1966 Jan;21(1):141-3. doi: 10.1016/s0021-9673(01)91277-4.
2
Inhibition by isoniazid of synthesis of mycolic acids in Mycobacterium tuberculosis.异烟肼对结核分枝杆菌中分枝菌酸合成的抑制作用。
J Gen Microbiol. 1970 Sep;63(1):41-8. doi: 10.1099/00221287-63-1-41.
3
Chemical analyses of mycobacterial cell walls.分枝杆菌细胞壁的化学分析
Biochim Biophys Acta. 1968 Apr 16;158(1):130-43. doi: 10.1016/0304-4165(68)90080-9.
4
Selective action of isoniazid on the synthesis of cell wall mycolates in mycobacteria.异烟肼对分枝杆菌细胞壁霉菌酸合成的选择性作用。
Ann N Y Acad Sci. 1974 May 10;235(0):426-38. doi: 10.1111/j.1749-6632.1974.tb43281.x.
5
Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis.异烟肼对结核分枝杆菌体内分枝菌酸合成、细胞生长及活力的影响。
Antimicrob Agents Chemother. 1972 Jul;2(1):29-35. doi: 10.1128/AAC.2.1.29.
6
Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties.分枝杆菌及相关生物体的细胞壁；化学性质与免疫刺激特性
Mol Cell Biochem. 1975 May 30;7(2):87-104. doi: 10.1007/BF01792076.
7
Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis.异烟肼在结核分枝杆菌中分枝菌酸合成过程中的抑制作用位点。
J Lipid Res. 1975 Jul;16(4):308-17.
8
Isolation and characterization of the monounsaturated long chain fatty acids of Mycobacterium tuberculosis.
Lipids. 1978 Sep;13(9):575-9. doi: 10.1007/BF02535818.
9
Effect of low temperature on growth, viability, and synthesis of mycolic acids of Mycobacterium tuberculosis strain H37Ra.低温对结核分枝杆菌H37Ra菌株生长、活力及分枝菌酸合成的影响
Am Rev Respir Dis. 1978 Jul;118(1):113-7. doi: 10.1164/arrd.1978.118.1.113.
10
Characterization of the purified components of a new homologous series of alpha-mycolic acids from Mycobacterium tuberculosis H37Ra.
J Biol Chem. 1978 Aug 10;253(15):5411-7.

异烟肼对结核分枝杆菌H37Ra中单不饱和长链脂肪酸合成的抑制作用。

Isoniazid inhibition of the synthesis of monounsaturated long-chain fatty acids in Mycobacterium tuberculosis H37Ra.

作者信息

Davidson L A, Takayama K

出版信息

Antimicrob Agents Chemother. 1979 Jul;16(1):104-5. doi: 10.1128/AAC.16.1.104.

DOI:10.1128/AAC.16.1.104
PMID:112917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352798/
Abstract

Isoniazid inhibited C(24) and C(26) monounsaturated fatty acid synthesis in Mycobacterium tuberculosis H37Ra. Time courses of this inhibition and that of mycolic acid synthesis were similar.

摘要

异烟肼抑制结核分枝杆菌H37Ra中C(24)和C(26)单不饱和脂肪酸的合成。这种抑制作用的时间进程与分枝菌酸合成的时间进程相似。