罗沙米星与红霉素对尿路病原体的体外比较
In vitro comparison of rosamicin and erythromycin against urinary tract pathogens.
作者信息
Eickhoff T C, Ehret J M
出版信息
Antimicrob Agents Chemother. 1979 Jul;16(1):69-73. doi: 10.1128/AAC.16.1.69.
The in vitro activity of rosamicin and erythromycin was compared at various pH values against 311 strains of bacteria representing common urinary tract pathogens. Alkalinization of the media consistently and significantly increased the antibacterial activity of rosamicin against all of the organisms tested. This was also true for erythromycin except when tested against strains of Proteus. At pH 8, rosamicin was two- to sixfold more active than erythromycin against Enterobacteriaceae. The activity of both antibiotics against Pseudomonas aeruginosa was very similar when tested at pH 8. Erythromycin was twice as active as rosamicin at pH 8 against group D streptococci. The activity of both antibiotics was bacteriostatic and inoculum size dependent, regardless of the organism tested or the pH of the test media. The greater activity of rosamicin against Enterobacteriaceae warrants clinical investigation.
在不同pH值条件下，比较了罗沙米星和红霉素对311株代表常见尿路病原体的细菌的体外活性。培养基碱化始终并显著提高了罗沙米星对所有测试菌株的抗菌活性。红霉素也是如此，但在测试变形杆菌菌株时除外。在pH 8时，罗沙米星对肠杆菌科细菌的活性比红霉素高两到六倍。在pH 8测试时，两种抗生素对铜绿假单胞菌的活性非常相似。在pH 8时，红霉素对D组链球菌的活性是罗沙米星的两倍。无论测试的菌株或测试培养基的pH值如何，两种抗生素的活性均为抑菌性且与接种量有关。罗沙米星对肠杆菌科细菌的更强活性值得进行临床研究。
Zotero 插件