Lorian V, Sabath L D
Appl Microbiol. 1970 Nov;20(5):754-6. doi: 10.1128/am.20.5.754-756.1970.
Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.
研究发现，红霉素在碱性培养基中对革兰氏阴性杆菌的抑制作用比在中性或酸性培养基中更强。在对最近研究的500株大肠杆菌、克雷伯菌-肠杆菌、铜绿假单胞菌和奇异变形杆菌的临床分离株进行的研究中，均观察到了明确的效果，但对大肠杆菌的效果最为显著。在pH值为8.5时，除14%的奇异变形杆菌菌株外，所有菌株都能被普通治疗剂量的红霉素在尿液中轻易达到的浓度所抑制。
