D'angelo S A, Wall N R, Bowers C Y
Proc Soc Exp Biol Med. 1975 Jan;148(1):227-35. doi: 10.3181/00379727-148-38512.
Acute administration of PGE-1 in graded doses (0.25-1.0 mg) to pregnant rats in late gestation (21st day) induced significant release of TSH, prolactin and LH from the maternal, pituitary. Plasma levels of PRL and TSH were elevated (three- to fivefold) in cesarean sectioned mothers given 4-5 sc injections of PGE-1; higher doses also stimulated LH release. Comparable increases in blood TSH and PRL levels were also found in their newborn but no indication of enhanced hormone release from the fetal hypophysis was noted. Histologic alterations were observed in the ovary (luteal cell hypertrophy, cytopasmic clearing, nuclear condensation, sinusoidal distension) of mothers receiving PGE-1 treatment. Thyroidal radioiodine accumulation in mother, fetus and neonate were usually decreased whereas thyroid: blood radioactivity ratios were consistently incrased. It is concluded that PGE-1 treatment of th pregnant rat near term stimulates release of hormones from the pituitary in mothers (TSH, LH, PRL) and in their newborn (TSH, PRL). The results also strongly suggest that PGE-1 administration may induce morphologic and functional changes in target endocrines (ovary, thyroid) by direct and separate actions.
在妊娠晚期（第21天）对怀孕大鼠急性给予不同剂量（0.25 - 1.0毫克）的前列腺素E-1（PGE-1），可诱导母体垂体显著释放促甲状腺激素（TSH）、催乳素和促黄体生成素（LH）。在接受4 - 5次皮下注射PGE-1的剖宫产母亲中，血浆催乳素和促甲状腺激素水平升高（三到五倍）；更高剂量还刺激促黄体生成素释放。在其新生幼崽中也发现血液中促甲状腺激素和催乳素水平有类似升高，但未观察到胎儿垂体激素释放增强的迹象。在接受PGE-1治疗的母亲卵巢中观察到组织学改变（黄体细胞肥大、细胞质清亮、核浓缩、血窦扩张）。母亲、胎儿和新生儿甲状腺对放射性碘的摄取通常减少，而甲状腺与血液的放射性比值持续增加。得出的结论是，在妊娠晚期对怀孕大鼠进行PGE-1治疗可刺激母体（TSH、LH、PRL）及其新生幼崽（TSH、PRL）垂体释放激素。结果还强烈表明，给予PGE-1可能通过直接且独立的作用在靶内分泌器官（卵巢、甲状腺）中诱导形态和功能变化。
