Zhu H, Bunn H F
Hematology Division of the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Science. 2001 Apr 20;292(5516):449-51. doi: 10.1126/science.1060849. Epub 2001 Apr 5.
How do organisms sense the amount of oxygen in the environment and respond appropriately when the amount of oxygen decreases (a condition called hypoxia)? In their Perspective, Zhu and Bunn discuss new findings (Ivan et al., Jaakkola et al.) that reveal how the HIF transcription factor, which switches on a group of hypoxia-response proteins, is itself regulated by changes in oxygen tension. The authors are in the Hematology Division of the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. E-mail: zhu@calvin.bwh.harvard.edu, bunn@calvin.bwh.harvard.edu
生物体如何感知环境中的氧气量，并在氧气量减少（一种称为缺氧的情况）时做出适当反应？在他们的《观点》文章中，朱和邦恩讨论了新的发现（伊万等人、亚科拉等人的研究），这些发现揭示了开启一组缺氧反应蛋白的低氧诱导因子（HIF）转录因子本身是如何受氧张力变化调节的。作者来自美国马萨诸塞州波士顿哈佛医学院布莱根妇女医院医学系血液科，邮编02115。电子邮件：zhu@calvin.bwh.harvard.edu，bunn@calvin.bwh.harvard.edu
