Clancy D J, Gems D, Harshman L G, Oldham S, Stocker H, Hafen E, Leevers S J, Partridge L
Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.
Science. 2001 Apr 6;292(5514):104-6. doi: 10.1126/science.1057991.
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
果蝇基因chico编码一种胰岛素受体底物，其在胰岛素/胰岛素样生长因子（IGF）信号通路中发挥作用。在线虫秀丽隐杆线虫中，胰岛素/IGF信号调节成虫寿命。我们发现，chico突变可使纯合子果蝇的平均寿命延长高达48%，杂合子延长36%。寿命延长并非chico雌性果蝇卵子发生受损的结果，也与抗逆性增加没有始终如一的相关性。chico纯合子的侏儒表型对于寿命延长也不是必需的。因此，胰岛素/IGF信号在调节动物衰老中的作用在进化上是保守的。
