Amant F, Moerman P, Davel G H, De Vos R, Vergote I, Lindeque B G, de Jonge E
Department of Obstetrics and Gynecology, Division Gynecological Oncology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
Int J Gynecol Pathol. 2001 Apr;20(2):186-90. doi: 10.1097/00004347-200104000-00012.
A 65-year-old black woman was found to have a 3.0 cm endometrial tumor that was a carcinosarcoma with a major epithelial and a less prominent mesenchymal component. The latter was undifferentiated but one focus of chondroid differentiation was noted. The former showed papillary serous differentiation. Melanin pigment was observed in both epithelial and mesenchymal components. Staining with antisera to S100 protein and HMB-45 confirmed the presence of melanocytes. An endocervical focus of tumor also contained melanin. Electron-microscopic studies showed large tumor cells with an irregularly indented nucleus and abnormal giant cytoplasmic melanosomes. Only one case of uterine carcinosarcoma with melanocytic differentiation has been previously reported.
一名65岁的黑人女性被发现患有一个3.0厘米的子宫内膜肿瘤，该肿瘤为癌肉瘤，主要为上皮成分，间叶成分不明显。后者未分化，但可见一处软骨样分化灶。前者表现为乳头状浆液性分化。上皮和间叶成分中均观察到黑色素沉着。用抗S100蛋白和HMB - 45抗血清染色证实存在黑素细胞。宫颈肿瘤灶也含有黑色素。电子显微镜研究显示，肿瘤细胞较大，核呈不规则凹陷，胞质内有异常巨大的黑素小体。此前仅报道过1例具有黑素细胞分化的子宫癌肉瘤。
