抗雌激素（萘福昔定）对蒙古沙鼠乳腺营养细胞中雌二醇诱导的核内包涵体的抑制作用。
Inhibition of estradiol-induced intranuclear inclusions by an anti-estrogen (nafoxidine) in mammotrophs of the Mongolian gerbil.
作者信息
Nickerson P A
出版信息
Proc Soc Exp Biol Med. 1975 Apr;148(4):29-30.
PMID:1129319
Abstract
Nafoxidine, an anti-estrogen, inhibited the induction of intranuclear inclusions by estradiol in mammotrophs of the male Mongolian gerbil. No inclusions were observed with inhibitor alone or in control-injected gerbils. Estrogen may well act directly on mammotrophs in induction of nuclear inclusions.
摘要
抗雌激素药物萘福昔定抑制了雌二醇在雄性蒙古沙鼠促乳素细胞中诱导核内包涵体的形成。单独使用抑制剂或在注射对照的沙鼠中均未观察到包涵体。雌激素很可能直接作用于促乳素细胞以诱导核内包涵体的形成。
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