Nickerson P A
Acta Anat (Basel). 1975;93(2):210-8. doi: 10.1159/000144481.
Intranuclear inclusions have been examined in mammotrophs of the Mongolian gerbil. No inclusions were identified in nuclei of newborn females, although inclusions were seen in the pituitary gland of young mature females. The number of inclusions in retired breeders was similar to that in young females. Estradiol benzoate increased the number of inclusions, although 10 mug/day for 5 or 14 days induced more inclusions than 5 or 100 mug for 14 days; significantly fewer inclusions were seen with the higher dose (2.81 +/- 0.10 inclusions per field for 10 mug and 2.19 +/- 0.01 inclusions for 100 mug). Significantly fewer inclusions were present at 3 and 4 weeks. The reduced number of inclusions may be attributable at least in part to cellular hypertrophy of mammotrophs which was especially prominent. Vacuolar inclusions predominated at 3 and 4 weeks and there were fewer membranous types than at previous times.
已对蒙古沙鼠促乳素细胞中的核内包涵体进行了检查。新生雌性的细胞核中未发现包涵体，不过在年轻成熟雌性的垂体中可见包涵体。老龄繁殖鼠中的包涵体数量与年轻雌性中的相似。苯甲酸雌二醇增加了包涵体的数量，尽管每天10微克，持续5天或14天比每天5微克或100微克持续14天诱导出更多的包涵体；高剂量时可见的包涵体明显更少（10微克时每视野2.81±0.10个包涵体，100微克时为2.19±0.01个包涵体）。在3周和4周时，包涵体数量明显减少。包涵体数量减少可能至少部分归因于促乳素细胞的细胞肥大，这种肥大尤为明显。在3周和4周时，空泡状包涵体占主导，膜性类型的包涵体比之前更少。
