Shimoyama T, Fukuda S, Tanaka M, Sugawara N, Kurimoto F, Munakata A
First Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
Eur J Gastroenterol Hepatol. 2001 Mar;13(3):227-31. doi: 10.1097/00042737-200103000-00002.
Lipopolysaccharides of Helicobacter pylori have an antigenic structure that mimics Lewis X occurring in gastric mucosa. The pathogenic role of antigenic mimicry in H. pylori-induced gastritis has been of recent interest. The aim of this study was to examine the relevance of anti-Lewis X antibody in the development of atrophic gastritis in H. pylori infection.
A total of 72 patients were studied. Serum samples were collected to measure IgG antibodies to H. pylori, CagA, VacA and Lewis X. Biopsy specimens were obtained from the antrum and the corpus to examine the grade and the type of atrophic gastritis.
Mean anti-Lewis X antibody titres were higher in 38 VacA-seropositive patients than in 13 seronegative patients (P < 0.05). The difference was not significant between patients with diffuse-type atrophic gastritis and those with multi-focal type. No significant correlation was observed between the titre of anti-Lewis X antibody and the grade of glandular atrophy, whereas CagA seropositivity was associated with glandular atrophy.
Anti-Lewis X antibody may play a role in persistent gastric inflammation, particularly in VacA-seropositive H. pylori infection. However, anti-Lewis X antibody does not seem itself to be associated with atrophic gastritis in patients with H. pylori infection.
幽门螺杆菌的脂多糖具有一种抗原结构，可模拟胃黏膜中出现的Lewis X。抗原模拟在幽门螺杆菌诱导的胃炎中的致病作用是近期研究的热点。本研究的目的是探讨抗Lewis X抗体在幽门螺杆菌感染所致萎缩性胃炎发生发展中的相关性。
共研究72例患者。采集血清样本以检测抗幽门螺杆菌、抗CagA、抗VacA和抗Lewis X的IgG抗体。从胃窦和胃体获取活检标本，以检查萎缩性胃炎的分级和类型。
38例VacA血清阳性患者的平均抗Lewis X抗体滴度高于13例血清阴性患者（P < 0.05）。弥漫型萎缩性胃炎患者与多灶型萎缩性胃炎患者之间的差异无统计学意义。抗Lewis X抗体滴度与腺体萎缩程度之间未观察到显著相关性，而CagA血清阳性与腺体萎缩相关。
抗Lewis X抗体可能在持续性胃炎症中起作用，尤其是在VacA血清阳性的幽门螺杆菌感染中。然而，抗Lewis X抗体本身似乎与幽门螺杆菌感染患者的萎缩性胃炎无关。
