Wardle C A, Fraser W D, Squire C R
Lancet. 2001 Mar 31;357(9261):1013-4. doi: 10.1016/S0140-6736(00)04248-3.
Measurement of thyrotropin concentration alone as a first-line thyroid-function test fails to indicate hypopituitarism in a number of patients. Using a combination of thyrotropin and thyroxine assays, we analysed 56,000 tests for a population of 471,000 over 12 months. 15 patients with clinically unsuspected hypopituitarism were detected, indicating that the occurrence of hypopituitarism might be underestimated.
仅将促甲状腺激素浓度测量作为一线甲状腺功能测试，无法在许多患者中检测出垂体功能减退。我们结合促甲状腺激素和甲状腺素检测，在12个月内对47.1万人进行了5.6万次检测。检测出15例临床未怀疑的垂体功能减退患者，这表明垂体功能减退的发生率可能被低估了。
