van Wendel de Joode B, Wesseling C, Kromhout H, Monge P, García M, Mergler D
Lancet. 2001 Mar 31;357(9261):1014-6. doi: 10.1016/S0140-6736(00)04249-5.
Dichlorodiphenyltrichloroethane (DDT) is a compound with moderate toxicity that is judged to be safe for occupational use, although little is known about its long-term effects on the human nervous system. We investigated chronic nervous-system effects of long-term occupational exposure to DDT by comparing the neurobehavioural performance of retired malaria-control workers with a reference group of retired guards and drivers. DDT-exposed workers did worse on tests assessing various neurobehavioural functions than controls; performance significantly deteriorated with increasing years of DDT application. Our results could not be explained by exposure to cholinesterase-inhibiting pesticides or other potential confounding factors.
滴滴涕（DDT）是一种具有中等毒性的化合物，尽管人们对其对人类神经系统的长期影响知之甚少，但它被判定为职业使用安全。我们通过比较退休疟疾防治工作者与退休警卫和司机参考组的神经行为表现，研究了长期职业接触滴滴涕对慢性神经系统的影响。接触滴滴涕的工人在评估各种神经行为功能的测试中的表现比对照组差；随着滴滴涕施用年限的增加，表现显著恶化。我们的结果无法用接触胆碱酯酶抑制性农药或其他潜在混杂因素来解释。
