Hikita T, Tadano-Aritomi K, Iida-Tanaka N, Anand J K, Ishizuka I
Division of Biomembrane Research, Pacific Northwest Research Institute, Seattle, Washington 98122-4327, USA.
J Biol Chem. 2001 Jun 22;276(25):23084-91. doi: 10.1074/jbc.M101288200. Epub 2001 Apr 9.
A novel plasmal conjugate of glycosphingolipid having cationic lipid properties was isolated from the white matter of bovine brain. Linkage analysis of galactosyl residue by methylation, liquid secondary ion, and electrospray ionization mass spectrometry of intact and methylated derivatives, and by (1)H- and (13)C-NMR spectroscopy, identified the structure unambiguously as an O-acetal conjugate of plasmal to the primary hydroxyl group of glycerol and to the 6-hydroxyl group of galactosyl residue of beta-galactosyl 1-->1 sphingosine (psychosine). This novel compound is hereby termed "glyceroplasmalopsychosine"; its structure is shown below (see text).
