Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine.

作者信息

Richter K K, Wang J, Fagerhol M K, Hauer-Jensen M

机构信息

Department of Surgery, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.

出版信息

Radiother Oncol. 2001 Apr;59(1):81-5. doi: 10.1016/s0167-8140(00)00302-9.

We examined whether early radiation-induced granulocyte transmigration (assessed by the fecal transferrin excretion ELISA assay) predicts subsequent development of (consequential) chronic radiation enteropathy. After accounting for the effect of radiation dose, transferrin excretion remained an independent predictor of overall tissue injury, intestinal fibrosis, and mucosal ulcers, but not TGF-beta immunoreactivity.