Lutgens Ludy, Lambin Philippe
Department of Radiation Oncology (Maastro), GROW Research Institute, University of Maastricht, Tanslaan 12, 6202 AZ Maastricht, The Netherlands.
World J Gastroenterol. 2007 Jun 14;13(22):3033-42. doi: 10.3748/wjg.v13.i22.3033.
Reduction of cancer treatment-induced mucosal injury has been recognized as an important target for improving the therapeutic ratio as well as reducing the economic burden associated with these treatment related sequellae. Clinical studies addressing this issue are hampered by the fact that specific objective parameters, which enable monitoring of damage in routine clinical practice, are lacking. This review summarizes pros and cons of currently available endpoints for intestinal injury. The metabolic background and characteristics of plasma citrulline, a recently investigated biomarker specifically for small intestinal injury, are discussed in more detail.
减少癌症治疗引起的黏膜损伤已被视为提高治疗比率以及减轻与这些治疗相关后遗症相关经济负担的重要目标。解决这一问题的临床研究受到缺乏能够在常规临床实践中监测损伤的特定客观参数这一事实的阻碍。本综述总结了目前可用的肠道损伤终点指标的优缺点。最近专门针对小肠损伤研究的生物标志物——血浆瓜氨酸的代谢背景和特征将进行更详细的讨论。