决明子叶甲醇提取物对大鼠胃肠道的影响。

Effect of methanolic extract of Cassia nigricans leaves on rat gastrointestinal tract.

作者信息

Nwafor P A, Okwuasaba F K

机构信息

Department of Pharmacology, College of Medical Sciences, University of Maiduguri PMB 1069, Maiduguri, Nigeria.

出版信息

Fitoterapia. 2001 Mar;72(3):206-14. doi: 10.1016/s0367-326x(00)00303-8.

DOI:10.1016/s0367-326x(00)00303-8

PMID:11295295

Abstract

The effects of the methanolic extract of Cassia nigricans leaves were investigated on experimentally-induced diarrhoea and ulceration in rat. The extract dose-dependently reduced both the small intestinal propulsive movement (P<0.01-0.001), and castor oil-induced fluid accumulation (P<0.05-0.001). Its inhibitory effects on intestinal propulsive movement and fluid accumulation were significantly (P<0.05) antagonised by yohimbine. However, castor oil-induced diarrhoea was increased. The extract also reduced significantly (P<0.05-0.001) the ulcers induced by both indomethacin and ethanol. The results indicate that the observed antidiarrhoeal effect might in part be due to alpha(2)-adrenoceptor stimulation.

摘要

研究了决明子叶甲醇提取物对大鼠实验性腹泻和溃疡的影响。该提取物剂量依赖性地降低了小肠推进运动（P<0.01 - 0.001）和蓖麻油诱导的液体蓄积（P<0.05 - 0.001）。育亨宾可显著（P<0.05）拮抗其对肠道推进运动和液体蓄积的抑制作用。然而，蓖麻油诱导的腹泻却增加了。该提取物还显著（P<0.05 - 0.001）减轻了吲哚美辛和乙醇诱导的溃疡。结果表明，观察到的止泻作用可能部分归因于α(2)-肾上腺素能受体的刺激。