Nopoulos P C, Rideout D, Crespo-Facorro B, Andreasen N C
Mental Health Clinical Research Center, University of Iowa College of Medicine, 52242, Iowa City, IA, USA
Schizophr Res. 2001 Mar 30;48(2-3):177-85. doi: 10.1016/s0920-9964(00)00067-0.
To evaluate sexual dimorphism and incidence of absent massa intermedia (MI), a midline thalamic structure, in patients with schizophrenia and healthy controls.
Thin slice magnetic resonance images of the brain were obtained. The presence of MI was determined by viewing sagittal, coronal, and axial planes.
In healthy controls, females had a significantly lower incidence of absent MI (13.56%) compared with males (32.08%). In patients with schizophrenia, there was a sex by diagnosis interaction. Female patients had significantly higher incidence of absent MI (32.76%) compared with their healthy controls (13.56%), whereas the male patients showed no difference in incidence of absent MI compared with their controls.
The MI, a sexually dimorphic midline structure, is more commonly absent in female patients with schizophrenia. These results support the growing literature reporting structural aberration of the thalamus, as well as other midline structures in the brains of patients with schizophrenia.
评估精神分裂症患者及健康对照者中中间块（MI，一种丘脑中线结构）的性别差异及缺如发生率。
获取脑部薄层磁共振图像。通过观察矢状面、冠状面和轴位面来确定MI的存在情况。
在健康对照者中，女性MI缺如的发生率（13.56%）显著低于男性（32.08%）。在精神分裂症患者中，存在诊断与性别的交互作用。女性患者MI缺如的发生率（32.76%）显著高于其健康对照者（13.56%），而男性患者MI缺如的发生率与其对照者相比无差异。
MI作为一种具有性别差异的中线结构，在女性精神分裂症患者中更常见缺如。这些结果支持了越来越多关于精神分裂症患者大脑中丘脑以及其他中线结构存在结构畸变的文献报道。
