de Souza Crippa José Alexandre, Zuardi Antonio Waldo, Busatto Geraldo F, Sanches Rafael Faria, Santos Antonio Carlos, Araújo David, Amaro Edson, Hallak Jaime Eduardo Cecílio, Ng Virginia, McGuire Philip K
Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Eur Psychiatry. 2006 Jul;21(5):291-9. doi: 10.1016/j.eurpsy.2005.09.010. Epub 2006 Jan 6.
Several studies have independently suggested that patients with schizophrenia are more likely to have an enlarged cavum septum pellucidum (CSP) and an absent adhesio interthalamica (AI), respectively. However, neither finding has been consistently replicated and it is unclear whether there is an association between these two midline brain abnormalities. Thus, we compared the prevalence of absent AI and the prevalence, size and volume of CSP in 38 patients with schizophrenia and 38 healthy controls using magnetic resonance imaging (MRI). There were no between group differences in the presence or volume of CSP; however, an enlarged CSP was commoner among patients than controls. There was also a positive correlation between CSP ratings and volumes. No differences in the presence or absence of the AI were found between patients and controls; however, an absent AI was commoner in male patients with schizophrenia than females. There was absolutely no overlap between the presence of a large CSP and an absence of AI. In conclusion, our findings are in line with several case series and other MRI investigations that have shown a higher incidence of putatively developmental brain abnormalities in patients with schizophrenia, particularly in males, and support the neurodevelopmental model of this disorder.
多项研究分别独立表明，精神分裂症患者更有可能出现透明隔腔（CSP）增大和丘脑间粘合（AI）缺失的情况。然而，这两种情况均未得到一致的重复验证，且尚不清楚这两种中线脑异常之间是否存在关联。因此，我们使用磁共振成像（MRI）比较了38例精神分裂症患者和38名健康对照者中AI缺失的患病率以及CSP的患病率、大小和体积。两组在CSP的存在或体积方面没有差异；然而，CSP增大在患者中比在对照者中更为常见。CSP评级与体积之间也存在正相关。患者和对照者在AI的存在与否方面没有差异；然而，AI缺失在男性精神分裂症患者中比女性更为常见。CSP增大与AI缺失之间完全没有重叠。总之，我们的研究结果与多个病例系列以及其他MRI研究一致，这些研究表明精神分裂症患者中假定的发育性脑异常发生率较高，尤其是在男性中，并支持这种疾病的神经发育模型。
