Munro I C, Kennepohl E
CanTox Health Sciences International, 2233 Argentia Road, Suite 308, Mississauga, ON, Canada.
Food Chem Toxicol. 2001 Apr;39(4):331-54. doi: 10.1016/s0278-6915(00)00145-9.
A study was conducted to determine the margins of safety between no-observed-effect levels (NOELs) and daily per capita intake of flavouring substances evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) using the safety evaluation procedure for flavouring substances. The safety evaluation procedure provides a practical method for integrating data on intake, structure-activity relationships, metabolism and toxicity to evaluate flavouring substances. The comparison of NOELs to intake reinforces the fact that the margins of safety between intake of flavouring substances and their representative NOELs is very large. 98% of flavouring substances have margins of safety greater than 1000, illustrating that even if intake was underestimated by several fold, in almost every case, a wide margin of safety would still exist.
开展了一项研究，以确定未观察到效应水平（NOELs）与联合国粮食及农业组织/世界卫生组织食品添加剂联合专家委员会（JECFA）使用调味剂安全评估程序评估的人均每日调味剂摄入量之间的安全边际。该安全评估程序提供了一种实用方法，用于整合关于摄入量、构效关系、代谢和毒性的数据，以评估调味剂。将NOELs与摄入量进行比较，进一步证明了调味剂摄入量与其代表性NOELs之间的安全边际非常大这一事实。98%的调味剂安全边际大于1000，这表明即使摄入量被低估了几倍，在几乎所有情况下，仍将存在很大的安全边际。
