Rashedy Ahmed H, Solimany Adnan A, Ismail Ayman K, Wahdan Mohamed H, Saban Khalid A
Department of Pathology, College of Medicine, Taif University, KSA.
Int J Clin Exp Pathol. 2013 Jul 15;6(8):1467-80. Print 2013.
Contamination of the environment with antimony compounds may affect human health through the persistent exposure to small doses over a long period. Sixty growing male albino rats, weighing 43-57 grams, utilized in this study. The animals were divided into 3 groups; each of 20 rats: animals of group I served as control, animals of group II received 6 mg/kg body weight antimony trisulfide daily for 8 weeks with drinking water, and those of group III received the same dose by the same route for 12 weeks. The Malpighian renal corpuscles showed distortion, destruction and congestion of glomerular tuft, vacuoles in the glomeruli, peritubular haemorrhage, obliteration of Bowman's space, and thickening with irregularity of Bowman's membrane. The proximal convoluted tubules demonstrated patchy loss of their brush border, thickening of the basement membrane with loss of its basal infoldings, disarrangement of the mitochondria, pleomorphic vacuoles in the cytoplasm, apical destruction of the cells, apical migration of the nuclei, and absence of microvilli. On the other hand, peri-tubular hemorrhage, apical vacuolation, small atrophic nuclei, swelling of mitochondria, obliteration of the lumina, destruction of cells, and presence of tissue debris in the lumina, were observed in the distal convoluted tubules. The present work demonstrated the hazardous effect of antimony on the renal function as evidenced by the significant increase of the level of blood urea, serum creatinine, and serum sodium and potassium. In conclusion, this study proposed that continuous oral administration of antimony for 8 and 12 weeks has hazardous toxic effect on the structure and function of the kidney in growing albino rat. Based on the results of the present study, it is recommended to avoid the use of any drinking water contaminated with antimony compounds and forbidden its use in infants and children foods.
锑化合物对环境的污染可能会因长期持续接触小剂量的锑而影响人类健康。本研究使用了60只体重在43 - 57克之间的成年雄性白化大鼠。这些动物被分为3组，每组20只：第一组动物作为对照，第二组动物每天通过饮用水接受6毫克/千克体重的三硫化锑，持续8周，第三组动物通过相同途径接受相同剂量，持续12周。马尔皮基肾小体表现出肾小球丛的扭曲、破坏和充血，肾小球内出现空泡，肾小管周围出血，鲍曼间隙闭塞，鲍曼膜增厚且不规则。近端曲管显示其刷状缘局部缺失，基底膜增厚且基底褶消失，线粒体排列紊乱，细胞质中出现多形性空泡，细胞顶端破坏，细胞核顶端迁移，且无微绒毛。另一方面，在远端曲管中观察到肾小管周围出血、顶端空泡化、小萎缩核、线粒体肿胀、管腔闭塞、细胞破坏以及管腔内存在组织碎片。本研究表明锑对肾功能有有害影响，血尿素、血清肌酐以及血清钠和钾水平的显著升高证明了这一点。总之，本研究提出，对白化大鼠连续口服锑8周和12周对其肾脏的结构和功能有有害的毒性作用。基于本研究结果，建议避免使用任何被锑化合物污染的饮用水，并禁止在婴幼儿食品中使用。
