Garantziotis S, Howell D N, McAdams H P, Davis R D, Henshaw N G, Palmer S M
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Chest. 2001 Apr;119(4):1277-80. doi: 10.1378/chest.119.4.1277.
Influenza infection is increasingly recognized to cause significant morbidity and mortality in the community, especially in pediatric patients and elderly persons. Influenza infection, however, has not been well described among thoracic organ transplant recipients. We provide the first detailed clinical, radiographic, and histologic description of influenza pneumonia among three lung transplant recipients. The presentation varied considerably among the three patients and, in some cases, was atypical for influenza. Despite treatment, a persistent decline in pulmonary function occurred in all three patients after the acute illness. Interestingly, on follow-up biopsy specimens, each patient had histologic evidence of acute rejection and/or obliterative bronchiolitis. Additional research, therefore, is needed to clarify the relationship between influenza infection, acute rejection, and obliterative bronchiolitis.
流感感染越来越被认为会在社区中导致严重的发病和死亡，尤其是在儿科患者和老年人中。然而，流感感染在胸器官移植受者中的情况尚未得到充分描述。我们首次详细描述了三名肺移植受者患流感肺炎的临床、影像学和组织学特征。三名患者的表现差异很大，在某些情况下，不符合典型的流感症状。尽管进行了治疗，但所有三名患者在急性疾病后肺功能持续下降。有趣的是，在随访活检标本中，每名患者都有急性排斥反应和/或闭塞性细支气管炎的组织学证据。因此，需要进一步的研究来阐明流感感染、急性排斥反应和闭塞性细支气管炎之间的关系。
