Vandervest Katherine M, Zamora Martin R
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Hospital, Anschutz Medical Campus, 1635 Aurora Ct, Suite 7020, Mail Stop F-749, Aurora, CO 80045 USA.
Curr Respir Care Rep. 2012;1(3):162-167. doi: 10.1007/s13665-012-0017-x. Epub 2012 Jun 20.
Community-acquired respiratory viruses (CARVs) are common pathogens in lung transplant recipients. Infection due to these viruses is associated with multiple complications including: rhinitis, pharyngitis, bronchitis, pneumonia, respiratory failure and even death. CARVs have also become increasingly recognized as a risk factor for acute rejection (AR) and bronchiolitis obliterans syndrome (BOS). Newer diagnostic techniques have enhanced the accuracy of diagnosis, but proven treatment options for CARVs are limited. Further insight into the immune response and allograft dysfunction associated with CARV infections is needed in order to develop novel management strategies which can reduce the morbidity and mortality caused by these infectious agents.
社区获得性呼吸道病毒(CARVs)是肺移植受者中的常见病原体。这些病毒引起的感染与多种并发症相关,包括:鼻炎、咽炎、支气管炎、肺炎、呼吸衰竭甚至死亡。CARVs也日益被认为是急性排斥反应(AR)和闭塞性细支气管炎综合征(BOS)的一个危险因素。更新的诊断技术提高了诊断的准确性,但针对CARVs的经证实的治疗选择有限。为了制定能够降低这些感染因子所致发病率和死亡率的新管理策略,需要进一步深入了解与CARV感染相关的免疫反应和同种异体移植功能障碍。