Shirai S, Sukoh N, Yamamoto H, Suzuki I, Kamimura A, Yoshida K, Suzuki A, Inoue M, Watanabe N
Department of Internal Medicine, Iwamizawa Municipal General Hospital, Iwamizawa.
Nihon Kokyuki Gakkai Zasshi. 2001 Jan;39(1):40-4.
A 55-year-old man presenting with 4 weeks of progressive dysarthria, gait ataxia and vertigo was admitted to our hospital. Chest X-ray films revealed a mass shadow in the right upper lobe of the lung, and transbronchial brushing specimens showed small-cell carcinoma. Extensive examination revealed metastatic lesions in the mediastinal lymph nodes and liver, but brain MRI showed no findings suggestive of metastasis or atrophy. A diagnosis of PCD associated with SCLC was made, and the patient had a high titer of anti-P/Q-type VGCC antibody. He was treated by chemotherapy and radiation therapy, which resulted in a transient improvement in the PCD symptoms.
一名55岁男性因进行性构音障碍、步态共济失调和眩晕4周入院。胸部X线片显示右肺上叶有肿块阴影，经支气管刷检标本显示为小细胞癌。全面检查发现纵隔淋巴结和肝脏有转移灶，但脑部MRI未发现提示转移或萎缩的迹象。诊断为与小细胞肺癌相关的副肿瘤性小脑变性，患者抗P/Q型电压门控性钙通道抗体滴度很高。他接受了化疗和放疗，副肿瘤性小脑变性症状暂时有所改善。
