Palm O, Moum B, Jahnsen J, Gran J T
Department of Rheumatology, Ostfold Central Hospital, Sarpsborg, Norway.
J Rheumatol. 2001 Mar;28(3):590-4.
To assess the prevalence of fibromyalgia (FM) and chronic widespread pain (CWP) in a population based cohort of patients with inflammatory bowel disease (IBD).
Patients in a prospective survey on newly diagnosed IBD were, 5 years after study entry, invited to a clinical examination including the investigation of musculoskeletal manifestations. A total of 521 patients were examined, corresponding to 80% of surviving cases with definite diagnoses of ulcerative colitis (UC) and Crohn's disease (CD). The diagnoses of FM and CWP strictly followed the American College of Rheumatology classification criteria of 1990.
At clinical examination, FM was diagnosed in 18 patients (3.5%), 3.7% with UC and 3.0% with CD. The prevalence was 6.4% in females and 0.4% in males. Thirty-eight patients (7.3%) had CWP (8.5% with UC; 4.8% with CD). The female:male ratio was 27:3 in the UC group and 8:0 in CD. In 19 patients (50%), CWP occurred after onset of IBD. No correlation with the extent of intestinal inflammation and the occurrence of FM and CWP was found.
The prevalences of FM and CWP in patients with IBD were similar to those of the general population. There were no differences in prevalence of FM and CWP between UC and CD. Chronic idiopathic inflammation of the intestine does not appear to predispose to chronic widespread pain.
评估炎症性肠病（IBD）患者人群队列中纤维肌痛（FM）和慢性广泛性疼痛（CWP）的患病率。
对新诊断的IBD患者进行前瞻性调查，在研究入组5年后，邀请他们进行临床检查，包括肌肉骨骼表现的调查。共检查了521例患者，相当于确诊为溃疡性结肠炎（UC）和克罗恩病（CD）的存活病例的80%。FM和CWP的诊断严格遵循1990年美国风湿病学会分类标准。
在临床检查中，18例患者（3.5%）被诊断为FM，其中UC患者为3.7%，CD患者为3.0%。女性患病率为6.4%，男性为0.4%。38例患者（7.3%）有CWP（UC患者为8.5%；CD患者为4.8%）。UC组的男女比例为27:3，CD组为8:0。19例患者（50%）的CWP在IBD发病后出现。未发现肠道炎症程度与FM和CWP的发生之间存在相关性。
IBD患者中FM和CWP的患病率与普通人群相似。UC和CD之间FM和CWP的患病率没有差异。肠道慢性特发性炎症似乎不会导致慢性广泛性疼痛。
