Sarkisov D S, Pal'tsyn A A, Popova I V, Badikova A K, Vtiurin B V
Arkh Patol. 1975;37(1):80-7.
The effect of frequency of administration of tetrachloride of carbon (CCl4) on synthesis of DNA by hepacytes and cells of the stroma, as well as on composition and magnitude of infiltrates in the liver of mice was studied. For this purpose autoradiographic and histological studies of the liver tissue in animals injected with poison once a week, twice a week and every day were carried out dayly. Periodic increases in number of hepacytes tagged with thymidin-H3 and an increase in the number of cells in infiltrates were observed. The rhythm of these changes corresponded to the frequency of administration of CCl4. With the rise in the frequency of injections of the poison the rate of increase in number of cells in infiltrates rose and synthesis of DNA in hepacytes became more intensive. The time interval, however, between the injection of the toxin and the rise of DNA synthesis in hepacytes remained constant irrespective of the frequency of exposure to the damaging factor.
研究了四氯化碳（CCl4）给药频率对肝细胞和基质细胞DNA合成的影响，以及对小鼠肝脏浸润物组成和大小的影响。为此，对每周注射一次、每周注射两次和每天注射毒物的动物的肝脏组织进行了每日的放射自显影和组织学研究。观察到用3H-胸腺嘧啶核苷标记的肝细胞数量定期增加，浸润物中的细胞数量增加。这些变化的节律与CCl4的给药频率相对应。随着毒物注射频率的增加，浸润物中细胞数量的增加速率上升，肝细胞中的DNA合成变得更加活跃。然而，无论接触损伤因子的频率如何，毒素注射与肝细胞中DNA合成增加之间的时间间隔保持不变。
