Landman R E, Wardlaw S L, McConnell R J, Khandji A G, Bruce J N, Freda P U
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
J Clin Endocrinol Metab. 2001 Apr;86(4):1470-6. doi: 10.1210/jcem.86.4.7389.
An 86-yr-old woman presented with fever of unknown origin. When laboratory evaluation revealed partial hypopituitarism, a magnetic resonance imaging scan of the head was performed and revealed a sellar mass consistent with a pituitary adenoma. Only after other possible etiologies for fever were excluded did she undergo transsphenoidal resection of the sellar mass, which proved to be a B-cell lymphoma. Primary central nervous system lymphoma of the pituitary region is a rare cause of a sellar mass, and this is the first reported case of pituitary lymphoma whose presenting manifestation was fever of unknown origin. Several disease processes can manifest themselves as fever and a sellar mass, including lymphomas. In our case, only surgical biopsy could make a diagnosis and distinguish this process from the more common pituitary adenoma.
一名86岁女性因不明原因发热就诊。实验室检查发现部分垂体功能减退后，进行了头部磁共振成像扫描，发现鞍区有一肿块，符合垂体腺瘤表现。在排除了其他可能导致发热的病因后，她接受了经蝶窦鞍区肿块切除术，结果显示为B细胞淋巴瘤。垂体区原发性中枢神经系统淋巴瘤是鞍区肿块的罕见病因，这是首例以不明原因发热为首发表现的垂体淋巴瘤病例。包括淋巴瘤在内的几种疾病过程都可能表现为发热和鞍区肿块。在我们的病例中，只有手术活检才能做出诊断，并将此过程与更常见的垂体腺瘤区分开来。
