Jana D, Nandi D, Maiti R K, Ghosh D
Reproductive Endocrinology and Family Welfare Unit, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore- 721 102, West Bengal, India.
Reprod Toxicol. 2001 Mar-Apr;15(2):215-9. doi: 10.1016/s0890-6238(01)00115-0.
Lithium chloride, a compound with clinical use in bipolar disorder, produces adverse effects on ovarian function in amphibian and rodent models. This study examined the effect of human chorionic gonadotrophin coadministration on ovarian steroidogenic and gametogenic activities in lithium chloride-treated rats. Relative ovarian and uterine weights, ovarian Delta(5)-3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase activities, folliculogenesis, uterine diameter, endometrial and myometrial thickness, and uterine luminal epithelial height were decreased significantly after lithium chloride treatment for 28 days at 1.6 mg/kg/day, the human therapeutic dose. These parameters were unchanged from the control level when subcutaneous (s.c.) human chorionic gonadotrophin (hCG) at 25 microg/kg/day was coadministered with the lithium chloride. The duration of the oestrous cycle was increased in lithium chloride-treated rat with longer metestrous and diestrous phases. Administration of hCG with lithium chloride prevented these estrous cycle alterations. We conclude that hCG can protect ovarian steroidogenic and gametogenic function after lithium chloride treatment.
氯化锂是一种用于双相情感障碍临床治疗的化合物，在两栖动物和啮齿动物模型中会对卵巢功能产生不良影响。本研究检测了人绒毛膜促性腺激素（hCG）联合给药对氯化锂处理的大鼠卵巢类固醇生成和配子发生活性的影响。以人类治疗剂量1.6 mg/kg/天对大鼠进行28天的氯化锂处理后，卵巢和子宫相对重量、卵巢Δ5-3β-羟基类固醇脱氢酶和17β-羟基类固醇脱氢酶活性、卵泡发生、子宫直径、子宫内膜和肌层厚度以及子宫腔上皮高度均显著降低。当每天皮下注射25 μg/kg的人绒毛膜促性腺激素（hCG）与氯化锂联合给药时，这些参数与对照水平相比没有变化。氯化锂处理的大鼠发情周期延长，动情后期和间情期延长。hCG与氯化锂联合给药可防止这些发情周期改变。我们得出结论，hCG可以在氯化锂处理后保护卵巢类固醇生成和配子发生功能。
