Larsson K S
Toxicology. 1975;4(1):75-81. doi: 10.1016/0300-483x(75)90023-2.
A teratology study on amaranth and Ponceau 4R was carried out in NMRI mice. The substances were given by gavage either from day 0 through day 7 or from day 6 through day 18 in doses of 7.5, 30 or 100 mg/kg. Distilled water was given by gavage to the control dams from day 0 through day 18. The foetuses were removed on day 18 for detailed examinations. No effect of treatment with the dyes could be observed with regard to number of implantations, frequency of foetal death and resorptions, gross malformations, skeletal or internal malformations or retarded growth as judged by foetal weight. The results are discussed with particular reference to the evaluation of teratologic studies on food colouring in general and the various regulation proposals from the National Food Administration.
对苋菜红和丽春红4R进行了一项NMRI小鼠致畸学研究。这些物质在第0天至第7天或第6天至第18天通过灌胃给予，剂量为7.5、30或100mg/kg。从第0天至第18天，给对照母鼠灌胃蒸馏水。在第18天取出胎儿进行详细检查。根据胎儿体重判断，染料处理对着床数量、胎儿死亡和吸收频率、严重畸形、骨骼或内部畸形或生长迟缓均无影响。结合对一般食用色素致畸学研究的评估以及国家食品管理局的各种监管建议对结果进行了讨论。
