大鼠食用色素丽春红4R的胚胎毒性研究。

A study of the embryotoxicity of the food colour Ponceau 4 R in rats.

作者信息

Meyer O, Hansen E V

出版信息

Toxicology. 1975 Nov;5(2):201-7. doi: 10.1016/0300-483x(75)90117-1.

PMID:1209650

Abstract

An embryotoxicity study on Ponceau 4 R was carried out in SPF Wistar rats. The substance was given by gavage from day 1 to 20 of the gestation period in doses of 0, 1000, 2000, and 4000 mg/kg bw per day, dissolved in distilled water. The foetuses were removed on day 21. No effect due to the treatment with the dye was observed with regard to the number of corpora luteae (CL), of implantations, of foetuses dead or alive with regard to gross malformations, to skeletal and internal malformations or to the weight of the foetuses.

摘要

对丽春红4R进行了一项胚胎毒性研究，实验对象为无特定病原体（SPF）的Wistar大鼠。在妊娠期第1天至第20天，通过灌胃给予该物质，剂量分别为0、1000、2000和4000毫克/千克体重/天，将其溶解于蒸馏水中。在第21天取出胎儿。未观察到该染料处理对黄体（CL）数量、着床数量、胎儿死活数量、总体畸形、骨骼和内部畸形或胎儿体重产生影响。