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关于Gy-a和Hy抗原以及界定它们的抗体的观察

Observations on the Gy-a and Hy antigens and the antibodies that define them.

作者信息

Moulds J J, Polesky H F, Reid M, Ellisor S S

出版信息

Transfusion. 1975 May-Jun;15(3):270-4. doi: 10.1046/j.1537-2995.1975.15375160364.x.

DOI:10.1046/j.1537-2995.1975.15375160364.x
PMID:1129835
Abstract

Two high frequency antigens, Hy (Holley) and Gy-a (Gregory), show an apparent association. All individuals lacking Gy-a are whites and these individuals are Hy-negative. A second group of Hy-negative individuals are blacks. All of these react weakly with anti-Gy-a. Neither Gy-a nor Hy are well developed on cord cells, although antibodies to both factors have been stimulated by pregnancy. Anti-Gy-a and anti-Hy antibodies react best in the antihuman globulin test. These antibodies have low avidity, high titers, and have been implicated as causing transfusion reactions.

摘要

两种高频抗原,Hy(霍利)和Gy-a(格雷戈里),表现出明显的关联。所有缺乏Gy-a的个体均为白人,且这些个体为Hy阴性。另一组Hy阴性个体为黑人。所有这些个体与抗Gy-a反应较弱。Gy-a和Hy在脐血细胞上均发育不良,尽管两种因子的抗体已因妊娠而被激发。抗Gy-a和抗Hy抗体在抗人球蛋白试验中反应最佳。这些抗体亲和力低、效价高,并被认为可导致输血反应。

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