van der Waal R I, van de Scheur M R, Pas H H, Jonkman M F, Van Groeningen C J, Nieboer C, Starink T M
Department of Dermatology, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Br J Dermatol. 2001 Apr;144(4):870-3. doi: 10.1046/j.1365-2133.2001.04148.x.
Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal bullous disease with heterogeneous clinical manifestations, characterized by linear deposition of IgA along the epidermal basement membrane zone. We report a patient with a metastasized renal cell carcinoma who developed an extensive blistering eruption. The lesions showed immunopathological findings characteristic of LABD. The patient showed a fair response to prednisolone and dapsone. Treatment to control the LABD was no longer required when interferon-alfa was started as palliative therapy for the metastasized renal cell carcinoma. The association of LABD and malignancies has been documented before and is not due to mere chance alone.
线状IgA大疱性皮病（LABD）是一种具有异质性临床表现的自身免疫性表皮下大疱病，其特征为IgA沿表皮基底膜带呈线状沉积。我们报告1例发生广泛水疱性皮疹的转移性肾细胞癌患者。病变显示出LABD的免疫病理学特征。该患者对泼尼松龙和氨苯砜反应良好。当开始使用干扰素-α作为转移性肾细胞癌的姑息治疗时，不再需要治疗来控制LABD。LABD与恶性肿瘤的关联以前已有文献记载，并非仅仅是偶然。
