[Ultrastructural and functional expression of the hepatocyte genome in conditions of prolonged inhibition of protein biosynthesis with cycloheximide. II].

The correlation of changes in sedimentary properties of polysome preparation and ultrastructure of the rough endoplasmatic reticulum in the rat liver cells was found in dynamics of the protein biosynthesis inhibition by cycloheximide (CH1). In particular, 6 hrs after CHI introduction the greatest fragmentation of the reticulum is accompanied by the greatest destruction of polysomes; however at the end of the 24-hour period a tendency is observed to restore the studied components of the protein synthesis system.