[环己酰亚胺长期抑制蛋白质生物合成条件下肝细胞基因组的超微结构与功能表达研究。III]
[Study of the ultrastructural and functional expression of the hepatocyte genome under conditions of prolonged depression of protein biosynthesis by cycloheximide. III].
作者信息
Galkin A P, Andrianov V M, Mitrokhin Iu I, Todorov I N
出版信息
Tsitol Genet. 1975 Jul-Aug;9(4):291-4.
PMID:1209736
Abstract
Dynamics of changes in mtRNA synthesis and mitochondria ultrastructure is strictly dependent on the level of inhibition of biosynthesis of cytoplasm proteins and "soluble" proteins of mitochondria by cycloheximide in hepatocytes: 1-6 hrs later a progressive weakening of protein synthesis is accompanied by a drop in mtRNA synthesis and essential destruction of mitochondria; from 12 to 24 hrs a partial restoration of protein biosynthesis induces the processes of the above-mentioned indexes normalization.
摘要
肝细胞中mtRNA合成和线粒体超微结构的变化动态严格依赖于环己酰亚胺对细胞质蛋白和线粒体“可溶性”蛋白生物合成的抑制水平：1 - 6小时后，蛋白质合成的逐渐减弱伴随着mtRNA合成的下降和线粒体的严重破坏；12至24小时，蛋白质生物合成的部分恢复诱导上述指标的正常化过程。
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