Llewelyn M, Cohen J
Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Crit Care. 2001;5(2):53-5. doi: 10.1186/cc986. Epub 2001 Feb 26.
The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-mediated diseases are likely to be directed at blocking the three-way interaction between superantigen, T cell receptor and major histocompatibility class II molecule, which inititates an excessive and disordered inflammatory response. In this article, we review the first published data to address one such strategy in the context of other recognised and experimental treatments.
革兰氏阳性菌产生超抗原性外毒素是中毒性休克综合征发病机制的基础。超抗原介导疾病的未来治疗策略可能旨在阻断超抗原、T细胞受体和主要组织相容性复合体II类分子之间的三方相互作用，这种相互作用会引发过度且紊乱的炎症反应。在本文中，我们回顾了首次发表的数据，以便在其他公认的和实验性治疗方法的背景下探讨这样一种策略。
