葡萄球菌和链球菌超抗原外毒素。
Staphylococcal and streptococcal superantigen exotoxins.
机构信息
Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
出版信息
Clin Microbiol Rev. 2013 Jul;26(3):422-47. doi: 10.1128/CMR.00104-12.
Abstract
SUMMARY This review begins with a discussion of the large family of Staphylococcus aureus and beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses. Finally, the review addresses current and possible novel strategies to prevent superantigen production and passive and active immunization strategies.
摘要
摘要 本文从结构和免疫生物学的角度讨论了金黄色葡萄球菌和乙型溶血性链球菌热原性细胞毒素 T 淋巴细胞超抗原这一家族，并以此为背景讨论了超抗原与已知的和可能的人类疾病的主要关联，包括与中毒性休克综合征、特应性皮炎、肺炎、感染性心内膜炎以及链球菌病的自身免疫后遗症的关联。最后，本文讨论了目前和可能的新策略，以防止超抗原的产生和被动及主动免疫策略。
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