Sundfeldt K, Ivarsson K, Rask K, Haeger M, Hedin L, Brännström M
Department of Physiology, University of Göteborg, Box 434, S-405 30 Göteborg, Sweden.
Anticancer Res. 2001 Jan-Feb;21(1A):65-70.
A major diagnostic dilemma in the clinical gynaecological oncology setting is to preoperatively determine whether a complex ovarian mass is benign or malignant. The cell-cell adhesion molecule E-cadherin has previously been localised in biopsies from both benign and malignant epithelial ovarian tumours. In this study, soluble E-cadherin levels was measured with ELISA-technique in peripheral blood, ascites and cystic fluids from patients (n = 33) undergoing surgery for ovarian cystic masses. The levels of soluble E-cadherin were significantly higher in cystic fluid from cystadenocarcinomas (p < 0.001) and borderline tumours (p < 0.05) as compared to cystic fluid from cystadenomas. In ascites fluid and peripheral blood no significant differences were seen. However, ratios of cystic fluid/peripheral blood levels were significantly higher in cystadenocarcinoma (p < 0.001) and borderline tumours (p < 0.05) as compared to benign tumours. In conclusion, measurements of soluble E-cadherin in cystic fluid from patients presenting with complex ovarian masses may be beneficial in increasing the accuracy of preoperative diagnosis.
临床妇科肿瘤学中一个主要的诊断难题是在术前确定复杂的卵巢肿物是良性还是恶性。细胞间粘附分子E-钙粘蛋白此前已在良性和恶性上皮性卵巢肿瘤的活检组织中定位。在本研究中，采用ELISA技术测量了33例接受卵巢囊性肿物手术患者外周血、腹水和囊液中的可溶性E-钙粘蛋白水平。与囊腺瘤的囊液相比，囊腺癌（p < 0.001）和交界性肿瘤（p < 0.05）囊液中的可溶性E-钙粘蛋白水平显著更高。在腹水和外周血中未观察到显著差异。然而，与良性肿瘤相比，囊腺癌（p < 0.001）和交界性肿瘤（p < 0.05）的囊液/外周血水平比值显著更高。总之，测量出现复杂卵巢肿物患者囊液中的可溶性E-钙粘蛋白可能有助于提高术前诊断的准确性。
