Daraï E, Bringuier A F, Walker-Combrouze F, Feldmann G, Madelenat P, Scoazec J Y
Service de Gynécologie-Obstétrique, Hôpital Bichat, Université Paris 7 Denis Diderot, France.
Hum Reprod. 1998 Oct;13(1O):2831-5. doi: 10.1093/humrep/13.10.2831.
The potential of the soluble forms of the adhesion molecules ICAM-1 (sICAM-1), CD44std (sCD44std) and E-cadherin (sE-cadherin) was tested for the diagnosis of benign and malignant cystic epithelial tumours of the ovary. Concentrations of sICAM-1, sCD44 std and sE-cadherin were measured by enzyme-linked immunosorbent assay (ELISA) in the serum and cyst fluid obtained from 23 patients with luteal cysts, 29 with cystadenomas, nine with dermoid cysts, five with borderline tumours and 11 with carcinomas. Serum concentrations of sICAM-1, but not of sCD44std and sE-cadherin, were constantly elevated compared with normal controls. Cyst fluid concentrations of sICAM-1, sCD44std and sE-cadherin were elevated in borderline and malignant tumours compared with cystadenomas (P = 0.034, 0.006 and 0.001, respectively). In conclusion, our results suggest that serum concentrations of adhesion molecules have no diagnostic value in ovarian tumours, whereas cyst fluid concentrations may facilitate distinction between benign lesions and borderline or malignant tumours.
对黏附分子ICAM-1（可溶性ICAM-1，sICAM-1）、CD44标准型（可溶性CD44标准型，sCD44std）和E-钙黏蛋白（可溶性E-钙黏蛋白，sE-cadherin）的可溶性形式用于诊断卵巢良恶性囊性上皮肿瘤的潜力进行了检测。通过酶联免疫吸附测定（ELISA）测量了23例黄体囊肿患者、29例囊腺瘤患者、9例皮样囊肿患者、5例交界性肿瘤患者和11例癌患者血清及囊液中sICAM-1、sCD44std和sE-cadherin的浓度。与正常对照组相比，sICAM-1的血清浓度持续升高，而sCD44std和sE-cadherin的血清浓度则不然。与囊腺瘤相比，交界性和恶性肿瘤中sICAM-1、sCD44std和sE-cadherin的囊液浓度升高（P分别为0.034、0.006和0.001）。总之，我们的结果表明，黏附分子的血清浓度在卵巢肿瘤中无诊断价值，而囊液浓度可能有助于区分良性病变与交界性或恶性肿瘤。
