McCooeye M A, Ells B, Barnett D A, Purves R W, Guevremont R
Institute for National Measurement Standards, National Research Council of Canada, Ottawa, Ontario.
J Anal Toxicol. 2001 Mar;25(2):81-7. doi: 10.1093/jat/25.2.81.
Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.
使用高场不对称波形离子迁移谱（FAIMS）与电喷雾电离（ESI）和质谱（MS）检测串联结合，已在人尿液基质中鉴定并测量了吗啡和可待因。向氮气载气中添加氦气可显著提高ESI-FAIMS-MS仪器测定吗啡和可待因的灵敏度。在人尿液中，吗啡的检测限为60 ng/mL，可待因的检测限为20 ng/mL，分析前无需对样品进行净化、衍生化或色谱分离。
