Yang X, Wu Z, Li Y, Tang J, Sun Y, Liu Z, Yin K
Beijing Neurosurgical Institute, Beijing, China.
Surg Neurol. 2001 Feb;55(2):116-22. doi: 10.1016/s0090-3019(00)00331-1.
Cellulose acetate polymer (CAP) is a new liquid embolic material that has been used experimentally in intravascular treatment of intracranial aneurysms. But this compound is still controversial in some aspects such as safety, efficiency, and histological changes. In this study, we re-evaluated the material with regard to intravascular treatment of aneurysms.
The carotid arteries of rats and experimental aneurysms in canines were embolized with CAP. The effects of CAP were evaluated according to angiographic and histological results.
A strong chemo-corrosive effect was observed. This led to severe damage to vessels and rupture of two thrombosed canine aneurysm models. There were significant technical difficulties including out-flow of CAP and a high rate of occlusion of the parent arteries.
We conclude that currently CAP is not an ideal embolic material for intracranial aneurysms. Further tests and improvements are needed before it can be widely used clinically.
醋酸纤维素聚合物（CAP）是一种新型液体栓塞材料，已在颅内动脉瘤血管内治疗中进行了实验性应用。但该化合物在安全性、有效性和组织学变化等某些方面仍存在争议。在本研究中，我们就其在动脉瘤血管内治疗方面对该材料进行了重新评估。
用CAP栓塞大鼠的颈动脉和犬的实验性动脉瘤。根据血管造影和组织学结果评估CAP的效果。
观察到强烈的化学腐蚀作用。这导致血管严重损伤以及两个血栓形成的犬动脉瘤模型破裂。存在显著的技术难题，包括CAP外流和母动脉高闭塞率。
我们得出结论，目前CAP并非颅内动脉瘤的理想栓塞材料。在其能够临床广泛应用之前，还需要进一步测试和改进。
