Prestigiacomo C J, Balmaceda C, Dalmau J
Department of Neurological Surgery, The Neurological Institute of New York, New York-Presbyterian Hospital, New York, New York, USA.
Cancer. 2001 Apr 15;91(8):1423-8. doi: 10.1002/1097-0142(20010415)91:8<1423::aid-cncr1148>3.0.co;2-f.
There are several case reports describing paraneoplastic syndromes in patients with various forms of bladder carcinoma. Current immunologic analyses have enabled the identification of the antineuronal autoantibodies associated with specific syndromes.
A patient with a history of bladder carcinoma presented with opsoclonus and myoclonus.
Workup confirmed the presence of anti-Ri antibodies in the patient's serum and cerebrospinal fluid. The target Ri antigen was found to be expressed by the tumor.
To the authors' knowledge, there are few reports in the literature describing the long-term clinical follow-up and postmortem evaluation in a patient with this form of paraneoplastic syndrome. More important, the authors believe the current study represents the first time that the presence of anti-Ri antibodies has been noted in a paraneoplastic syndrome associated with transitional cell carcinoma of the bladder.
有几例病例报告描述了各种类型膀胱癌患者的副肿瘤综合征。目前的免疫学分析已能够鉴定与特定综合征相关的抗神经元自身抗体。
一名有膀胱癌病史的患者出现眼阵挛和肌阵挛。
检查证实患者血清和脑脊液中存在抗Ri抗体。发现肿瘤表达靶Ri抗原。
据作者所知，文献中很少有关于这种类型副肿瘤综合征患者的长期临床随访和尸检评估的报告。更重要的是，作者认为当前的研究首次指出在与膀胱移行细胞癌相关的副肿瘤综合征中存在抗Ri抗体。
